Preheat oven to 450F.
Make the batter: In a large bowl, combine the flour, garlic powder, onion powder, paprika, salt, and cayenne. Whisk in the nondairy milk to create a batter.
Coat the cauliflower: Add the cauliflower florets to the bowl with the batter and gently toss to coat them evenly.
Add the breadcrumbs: Sprinkle in the breadcrumbs over the coated cauliflower and toss gently again until well covered.
Bake the cauliflower: Line a baking sheet with a silicone baking mat or parchment paper. Spread the cauliflower in a single layer on the prepared baking sheet and bake for 22-25 minutes, flipping once around the 15 minute mark.
Prepare the buffalo-inspired sauce: While the cauliflower bakes, combine all buffalo sauce ingredients (except cornstarch and cold water) in a small sauce pan. Bring to a simmer on the stovetop and cook for 3-5 minutes.
Thicken the sauce: In a separate small bowl, whisk together the cornstarch and cold water to make a slurry. Pour the slurry into the simmering sauce and cook 1 more minute to thicken.
Coat the cauliflower: Reserve a small amount of buffalo sauce off to the side for later. Toss the baked cauliflower with the rest of the sauce in a large bowl until evenly coated. Spread the cauliflower out on the baking sheet again and bake for another 7-8 minutes.
Add extra sauce if desired: Remove from the oven and toss in the remaining reserved sauce if desired (this provides extra flavor, but does make the experience messier!)
Serve and enjoy: Pair with optional vegan ranch for dipping and enjoy!